Se trata de un número muy especial dedicado al síndrome de Down y publicado por la revista Mental Retardation and Developmental Disabilities Research Reviews. Los autores más prestigiosos de Estados Unidos presentan el estado de la cuestión en cada uno de sus campos, en relación con los temas más candentes de la investigación biológica, cognitiva y social. Por su excepcional interés, relacionamos los títulos y autores de los distintos capítulos.

Introduction to the special issue on Down syndrome
MM Seltzer, D. Patterson, IT Lott

Genetic mechanisms involved in the phenotype of Down syndrome
D Patterson

Using mouse models to explore genotype-phenotype relationships in Down syndrome
A Salehi, M Faizi, PV Belichenko, WC Mobley

A year of unprecedented progress in Down syndrome basic research
RH Reeves, CG Gamer

Epidemiology of Down syndrome
SL Sherman, EG Allen, LH Bean, SB Freeman

Down syndrome: Cognitive phenotype
W Silverman

Alzheimer’s disease in Down syndrome: neurobiology and risk
WB Zigman, IT Lott

Language development in Down syndrome: from the prelinguistic period to the acquisition of literacy
L Abbeduto, SF Warren, FA Conners

Education and children with Down syndrome: neuroscience, development, and intervention
DJ Fidler, L Nadel

Psychiatric and behavioural disorders in person with Down syndrome
EM Dykens

Families of persons with Down syndrome: new perspectives, findings, and research and service needs
RM Hodapp

Toward a research agenda for Down syndrome
IT Lott, D Patterson, MM Seltzer